3BF6

Thrombin:suramin complex

Summary for 3BF6

• Entry DOI: 10.2210/pdb3bf6/pdb
• Related: 1PPB 2H9T
• Descriptor: Thrombin, LIGHT CHAIN, Thrombin, HEAVY CHAIN, PHE-PRO-ARG, ... (5 entities in total)
• Functional Keywords: thrombin, suramin, blood, coagulation, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, zymogen
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35593.53

Authors

Lima, L.M.T.R.,Polikarpov, I.,Monteiro, R.Q. (deposition date: 2007-11-20, release date: 2007-12-25, Last modification date: 2015-07-15)

• Primary citation: Lima, L.M.,Becker, C.F.,Giesel, G.M.,Marques, A.F.,Cargnelutti, M.T.,de Oliveira Neto, M.,Queiroz Monteiro, R.,Verli, H.,Polikarpov, I.; Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases.; Biochim.Biophys.Acta, 1794:873-881, 2009; PubMed: 19332154; DOI: 10.1016/j.bbapap.2009.03.011

Experimental method

X-RAY DIFFRACTION (2.5 Å)