3BEJ

Structure of human FXR in complex with MFA-1 and co-activator peptide

Summary for 3BEJ

Entry DOI	10.2210/pdb3bej/pdb
Descriptor	Bile acid receptor, Nuclear receptor coactivator 1, YTTRIUM (III) ION, ... (5 entities in total)
Functional Keywords	fxr, bar, nr1h4, bile acid receptor, nhr, nuclear receptor, activator, alternative splicing, dna-binding, metal-binding, nucleus, repressor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription regulator
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	62313.21
Authors	Soisson, S.M.,Parthasarathy, G.,Becker, J.W. (deposition date: 2007-11-19, release date: 2008-03-18, Last modification date: 2024-02-21)
Primary citation	Soisson, S.M.,Parthasarathy, G.,Adams, A.D.,Sahoo, S.,Sitlani, A.,Sparrow, C.,Cui, J.,Becker, J.W. Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation. Proc.Natl.Acad.Sci.Usa, 105:5337-5342, 2008 Cited by PubMed: 18391212 DOI: 10.1073/pnas.0710981105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation