3BCN

Crystal structure of a papain-like cysteine protease Ervatamin-A complexed with irreversible inhibitor E-64

Replaces:  2PSC

Summary for 3BCN

• Entry DOI: 10.2210/pdb3bcn/pdb
• Descriptor: Ervatamin-A, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, BETA-MERCAPTOETHANOL, ... (4 entities in total)
• Functional Keywords: protease-inhibitor complex, papain-like fold, plant cysteine protease, ervatamin, hydrolase, thiol protease
• Biological source: Tabernaemontana divaricata
• Total number of polymer chains: 2
• Total formula weight: 46505.28

Authors

Ghosh, R.,Chakrabarti, C.,Dattagupta, J.K.,Biswas, S. (deposition date: 2007-11-13, release date: 2007-11-27, Last modification date: 2023-11-01)

• Primary citation: Ghosh, R.,Chakraborty, S.,Chakrabarti, C.,Dattagupta, J.K.,Biswas, S.; Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria; Febs J., 275:421-434, 2008; PubMed: 18167146; DOI: 10.1111/j.1742-4658.2007.06211.x

Experimental method

X-RAY DIFFRACTION (2.85 Å)