3BC3

Exploring inhibitor binding at the S subsites of cathepsin L

Summary for 3BC3

Entry DOI	10.2210/pdb3bc3/pdb
Related	1MHW
Descriptor	Cathepsin L heavy and light chains, S-benzyl-N-(biphenyl-4-ylacetyl)-L-cysteinyl-N~5~-(diaminomethyl)-D-ornithyl-N-(2-phenylethyl)-L-tyrosinamide (3 entities in total)
Functional Keywords	cathepsin l inhibitor binding at the s subsites, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P07711
Total number of polymer chains	2
Total formula weight	50107.50
Authors	Chowdhury, S.F.,Joseph, L.,Kumar, S.,Tulsidas, S.R.,Bhat, S.,Ziomek, E.,Nard, R.M.,Sivaraman, J.,Purisima, E.O. (deposition date: 2007-11-12, release date: 2008-03-18, Last modification date: 2023-08-30)
Primary citation	Chowdhury, S.F.,Joseph, L.,Kumar, S.,Tulsidas, S.R.,Bhat, S.,Ziomek, E.,Menard, R.,Sivaraman, J.,Purisima, E.O. Exploring inhibitor binding at the S' subsites of cathepsin L J.Med.Chem., 51:1361-1368, 2008 Cited by PubMed: 18278855 DOI: 10.1021/jm701190v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation