3BBW

crystal structure of the ErbB4 kinase in its inactive conformation

Summary for 3BBW

• Entry DOI: 10.2210/pdb3bbw/pdb
• Related: 3BBT 3BCE
• Descriptor: Receptor tyrosine-protein kinase erbB-4 (1 entity in total)
• Functional Keywords: inactive kinase conformation, alternative splicing, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphorylation, receptor, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein . ERBB4 intracellular domain: Nucleus : Q15303
• Total number of polymer chains: 2
• Total formula weight: 74982.91

Authors

Qiu, C. (deposition date: 2007-11-11, release date: 2008-02-12, Last modification date: 2024-02-21)

• Primary citation: Qiu, C.,Tarrant, M.K.,Choi, S.H.,Sathyamurthy, A.,Bose, R.,Banjade, S.,Pal, A.,Bornmann, W.G.,Lemmon, M.A.,Cole, P.A.,Leahy, D.J.; Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.; Structure, 16:460-467, 2008; PubMed: 18334220; DOI: 10.1016/j.str.2007.12.016

Experimental method

X-RAY DIFFRACTION (4 Å)