3B65

Crystal structure of the androgen receptor ligand binding domain in complex with SARM S-24

Summary for 3B65

Entry DOI	10.2210/pdb3b65/pdb
Related	2axa 3B5R 3B66 3B67 3B68
Descriptor	Androgen receptor, (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide (3 entities in total)
Functional Keywords	androgen receptor, sarm, disease mutation, dna-binding, lipid-binding, metal-binding, nucleus, polymorphism, steroid-binding, transcription, transcription regulation, triplet repeat expansion, ubl conjugation, zinc, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10275
Total number of polymer chains	1
Total formula weight	29493.30
Authors	Bohl, C.E.,Miller, D.D.,Dalton, J.T. (deposition date: 2007-10-27, release date: 2008-09-09, Last modification date: 2024-02-21)
Primary citation	Bohl, C.E.,Wu, Z.,Chen, J.,Mohler, M.L.,Yang, J.,Hwang, D.J.,Mustafa, S.,Miller, D.D.,Bell, C.E.,Dalton, J.T. Effect of B-ring substitution pattern on binding mode of propionamide selective androgen receptor modulators Bioorg.Med.Chem.Lett., 18:5567-5570, 2008 Cited by PubMed: 18805694 DOI: 10.1016/j.bmcl.2008.09.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation