3B4Y

FGD1 (Rv0407) from Mycobacterium tuberculosis

Summary for 3B4Y

• Entry DOI: 10.2210/pdb3b4y/pdb
• Related: 3C8N
• Descriptor: PROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD1, COENZYME F420, CITRATE ANION, ... (4 entities in total)
• Functional Keywords: tim-barrel, non-prolyl cis-peptide bulge, f420 binding, oxidoreductase, structural genomics, tb structural genomics consortium, tbsgc
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 2
• Total formula weight: 81337.64

Authors

Bashiri, G.,Squire, C.J.,Moreland, N.M.,Baker, E.N.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2007-10-25, release date: 2008-04-22, Last modification date: 2024-04-03)

• Primary citation: Bashiri, G.,Squire, C.J.,Moreland, N.J.,Baker, E.N.; Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding; J.Biol.Chem., 283:17531-17541, 2008; PubMed: 18434308; DOI: 10.1074/jbc.M801854200

Experimental method

X-RAY DIFFRACTION (1.95 Å)