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3B13

Crystal structure of the DHR-2 domain of DOCK2 in complex with Rac1 (T17N mutant)

Summary for 3B13
Entry DOI10.2210/pdb3b13/pdb
DescriptorDedicator of cytokinesis protein 2, Ras-related C3 botulinum toxin substrate 1 (3 entities in total)
Functional Keywordsprotein-ptotein complex, lymphocyte chemotaxis, signal tansduction, guanine nucleotide exchange factor, gtpase, protein binding-signaling protein complex, protein binding/signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationEndomembrane system; Peripheral membrane protein: Q92608
Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity): P63000
Total number of polymer chains4
Total formula weight142696.75
Authors
Hanawa-Suetsugu, K.,Kukimoto-Niino, M.,Mishima-Tsumagari, C.,Terada, T.,Shirouzu, M.,Fukui, Y.,Yokoyama, S. (deposition date: 2011-06-24, release date: 2012-03-14, Last modification date: 2023-11-01)
Primary citationHanawa-Suetsugu, K.,Kukimoto-Niino, M.,Mishima-Tsumagari, C.,Akasaka, R.,Ohsawa, N.,Sekine, S.,Ito, T.,Tochio, N.,Koshiba, S.,Kigawa, T.,Terada, T.,Shirouzu, M.,Nishikimi, A.,Uruno, T.,Katakai, T.,Kinashi, T.,Kohda, D.,Fukui, Y.,Yokoyama, S.
Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.
Proc.Natl.Acad.Sci.USA, 109:3305-3310, 2012
Cited by
PubMed: 22331897
DOI: 10.1073/pnas.1113512109
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.006 Å)
Structure validation

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