3B0W

Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with digoxin

Summary for 3B0W

Entry DOI	10.2210/pdb3b0w/pdb
Descriptor	Nuclear receptor ROR-gamma, DIGOXIN (3 entities in total)
Functional Keywords	three-layered alpha helical sandwich, orphan nuclear receptor, ligand-binding domain, antagonist, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus : P51449
Total number of polymer chains	2
Total formula weight	58177.52
Authors	Fujita-Sato, S.,Ito, S.,Isobe, T.,Ohyama, T.,Wakabayashi, K.,Morishita, K.,Ando, O.,Isono, F. (deposition date: 2011-06-17, release date: 2011-07-06, Last modification date: 2023-11-01)
Primary citation	Fujita-Sato, S.,Ito, S.,Isobe, T.,Ohyama, T.,Wakabayashi, K.,Morishita, K.,Ando, O.,Isono, F. Structural Basis of Digoxin That Antagonizes ROR{gamma}t Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production J.Biol.Chem., 286:31409-31417, 2011 Cited by PubMed: 21733845 DOI: 10.1074/jbc.M111.254003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation