3AYU

Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor

Summary for 3AYU

Entry DOI	10.2210/pdb3ayu/pdb
Descriptor	72 kDa type IV collagenase, Amyloid beta A4 protein, ZINC ION, ... (5 entities in total)
Functional Keywords	protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Isoform 1: Secreted, extracellular space, extracellular matrix. Isoform 2: Cytoplasm: P08253 Membrane; Single-pass type I membrane protein: P05067
Total number of polymer chains	2
Total formula weight	20028.94
Authors	Hashimoto, H.,Takeuchi, T.,Komatsu, K.,Miyazaki, K.,Sato, M.,Higashi, S. (deposition date: 2011-05-17, release date: 2011-08-03, Last modification date: 2024-03-13)
Primary citation	Hashimoto, H.,Takeuchi, T.,Komatsu, K.,Miyazaki, K.,Sato, M.,Higashi, S. Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of {beta}-amyloid precursor protein-derived inhibitor J.Biol.Chem., 2011 Cited by PubMed: 21813640 DOI: 10.1074/jbc.M111.264176 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation