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3AQV

Human AMP-activated protein kinase alpha 2 subunit kinase domain (T172D) complexed with compound C

Summary for 3AQV
Entry DOI10.2210/pdb3aqv/pdb
Related2h6d 2yza
Descriptor5'-AMP-activated protein kinase catalytic subunit alpha-2, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine (3 entities in total)
Functional Keywordsstructural genomics, riken structural genomics/proteomics initiative, rsgi, transferase, signaling protein, serine/threonine protein kinase, phosphorylation, atp-binding, nucleotide-binding, cholesterol biosynthesis, fatty acid biosynthesis, lipid synthesis, glucose metabolism, magnesium, metal-binding, serine/threonine-protein kinase, steroid biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity): P54646
Total number of polymer chains1
Total formula weight31971.22
Authors
Handa, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Toyama, M.,Terada, T.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2010-11-19, release date: 2011-04-27, Last modification date: 2023-11-01)
Primary citationHanda, N.,Takagi, T.,Saijo, S.,Kishishita, S.,Takaya, D.,Toyama, M.,Terada, T.,Shirouzu, M.,Suzuki, A.,Lee, S.,Yamauchi, T.,Okada-Iwabu, M.,Iwabu, M.,Kadowaki, T.,Minokoshi, Y.,Yokoyama, S.
Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha 2 subunit kinase domain
Acta Crystallogr.,Sect.D, 67:480-487, 2011
Cited by
PubMed: 21543851
DOI: 10.1107/S0907444911010201
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.08 Å)
Structure validation

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