3ALQ

Crystal structure of TNF-TNFR2 complex

Summary for 3ALQ

Entry DOI	10.2210/pdb3alq/pdb
Related	1tnf 1tnr 2e7a 2zjc 2zpx
Descriptor	Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1B, COBALT (II) ION, ... (4 entities in total)
Functional Keywords	ligand-receptor complex, cytokine, cytokine-cytokine receptor complex, cytokine/cytokine receptor
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Tumor necrosis factor-binding protein 2: Secreted: P20333
Total number of polymer chains	12
Total formula weight	216741.20
Authors	Mukai, Y.,Nakamura, T.,Yamagata, Y.,Tsutsumi, Y. (deposition date: 2010-08-06, release date: 2010-11-17, Last modification date: 2023-11-01)
Primary citation	Mukai, Y.,Nakamura, T.,Yoshikawa, M.,Yoshioka, Y.,Tsunoda, S.I.,Nakagawa, S.,Yamagata, Y.,Tsutsumi, Y. Solution of the Structure of the TNF-TNFR2 Complex Sci.Signal., 3:ra83-ra83, 2010 Cited by PubMed: 21081755 DOI: 10.1126/scisignal.2000954 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation