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3AGM

Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670

Summary for 3AGM
Entry DOI10.2210/pdb3agm/pdb
Related3BWJ 3ag9 3agl
Related PRD IDPRD_001021
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, N~2~-{8-OXO-8-[4-(9H-PURIN-6-YL)PIPERAZIN-1-YL]OCTANOYL}-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGININAMIDE (3 entities in total)
Functional Keywordspka, protein kinase a, bisubstrate, bisubstrate inhibitor, arc-670, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P17612
Total number of polymer chains2
Total formula weight42110.15
Authors
Pflug, A.,Ragozina, J.,Uri, A.,Bossemeyer, D.,Engh, R.A. (deposition date: 2010-04-02, release date: 2010-09-01, Last modification date: 2023-11-15)
Primary citationPflug, A.,Rogozina, J.,Lavogina, D.,Enkvist, E.,Uri, A.,Engh, R.A.,Bossemeyer, D.
Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
J.Mol.Biol., 403:66-77, 2010
Cited by
PubMed: 20732331
DOI: 10.1016/j.jmb.2010.08.028
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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