3ADE

Crystal Structure of Keap1 in Complex with Sequestosome-1/p62

Summary for 3ADE

Entry DOI	10.2210/pdb3ade/pdb
Descriptor	Kelch-like ECH-associated protein 1, Sequestosome-1, SULFATE ION, ... (4 entities in total)
Functional Keywords	beta-propeller, kelch motif, transcription
Biological source	Mus musculus (mouse) More
Cellular location	Cytoplasm: Q9Z2X8 Q64337
Total number of polymer chains	2
Total formula weight	37402.49
Authors	Kurokawa, H.,Yamamoto, M. (deposition date: 2010-01-19, release date: 2010-03-16, Last modification date: 2023-11-01)
Primary citation	Komatsu, M.,Kurokawa, H.,Waguri, S.,Taguchi, K.,Kobayashi, A.,Ichimura, Y.,Sou, Y.S.,Ueno, I.,Sakamoto, A.,Tong, K.I.,Kim, M.,Nishito, Y.,Iemura, S.,Natsume, T.,Ueno, T.,Kominami, E.,Motohashi, H.,Tanaka, K.,Yamamoto, M. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat.Cell Biol., 12:213-223, 2010 Cited by PubMed: 20173742 DOI: 10.1038/ncb2021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation