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3ACK

Crystal structure of Pyrrolo pyrazine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Summary for 3ACK
Entry DOI10.2210/pdb3ack/pdb
Related3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3LCK
DescriptorProto-oncogene tyrosine-protein kinase LCK, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywordstyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, kinase, sh2 domain, sh3 domain, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P06239
Total number of polymer chains1
Total formula weight33614.17
Authors
Tsuji, E. (deposition date: 2010-01-05, release date: 2010-06-30, Last modification date: 2023-11-15)
Primary citationOzawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K.
Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase
To be Published,
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

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