3A99

Structure of PIM-1 kinase crystallized in the presence of P27KIP1 Carboxy-terminal peptide

Summary for 3A99

Entry DOI	10.2210/pdb3a99/pdb
Descriptor	Proto-oncogene serine/threonine-protein kinase pim-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
Functional Keywords	pim-1, p27kip1, peptide drug, prostate cancer, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	37013.89
Authors	Morishita, D.,Takami, M.,Yoshikawa, S.,Katayama, R.,Sato, S.,Kukimoto-Niino, M.,Umehara, T.,Shirouzu, M.,Sekimizu, K.,Yokoyama, S.,Fujita, N. (deposition date: 2009-10-22, release date: 2010-11-03, Last modification date: 2023-11-01)
Primary citation	Morishita, D.,Takami, M.,Yoshikawa, S.,Katayama, R.,Sato, S.,Kukimoto-Niino, M.,Umehara, T.,Shirouzu, M.,Sekimizu, K.,Yokoyama, S.,Fujita, N. Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase J.Biol.Chem., 286:2681-2688, 2011 Cited by PubMed: 21062737 DOI: 10.1074/jbc.M109.092452 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation