3A77

The crystal structure of phosphorylated IRF-3

Summary for 3A77

• Entry DOI: 10.2210/pdb3a77/pdb
• Descriptor: Interferon regulatory factor 3, ACETIC ACID, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
• Functional Keywords: phosphorylated protein, activator, antiviral defense, dna-binding, host-virus interaction, nucleus, phosphoprotein, transcription, transcription regulation
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : Q14653
• Total number of polymer chains: 4
• Total formula weight: 108422.13

Authors

Takahasi, K.,Horiuchi, M.,Noda, N.N.,Inagaki, F. (deposition date: 2009-09-17, release date: 2010-08-04, Last modification date: 2023-11-01)

• Primary citation: Takahasi, K.,Horiuchi, M.,Fujii, K.,Nakamura, S.,Noda, N.N.,Yoneyama, M.,Fujita, T.,Inagaki, F.; Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.; Genes Cells, 15:901-910, 2010; PubMed: 20604809; DOI: 10.1111/j.1365-2443.2010.01427.x

Experimental method

X-RAY DIFFRACTION (1.8 Å)