3A60

Crystal structure of unphosphorylated p70S6K1 (Form I)

Summary for 3A60

Entry DOI	10.2210/pdb3a60/pdb
Related	3A61 3A62
Descriptor	Ribosomal protein S6 kinase beta-1, STAUROSPORINE (3 entities in total)
Functional Keywords	kinase, kinase domain, inactive, active, ribosomal s6 kinase, activation, alternative initiation, atp-binding, cell junction, cytoplasm, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, synapse, synaptosome, transferase
Biological source	Homo sapiens (human)
Cellular location	Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443
Total number of polymer chains	2
Total formula weight	74806.34
Authors	Sunami, T.,Byrne, N.,Diehl, R.E.,Funabashi, K.,Hall, D.L.,Ikuta, M.,Patel, S.B.,Shipman, J.M.,Smith, R.F.,Takahashi, I.,Zugay-Murphy, J.,Iwasawa, Y.,Lumb, K.J.,Munshi, S.K.,Sharma, S. (deposition date: 2009-08-17, release date: 2009-10-27, Last modification date: 2023-11-01)
Primary citation	Sunami, T.,Byrne, N.,Diehl, R.E.,Funabashi, K.,Hall, D.L.,Ikuta, M.,Patel, S.B.,Shipman, J.M.,Smith, R.F.,Takahashi, I.,Zugay-Murphy, J.,Iwasawa, Y.,Lumb, K.J.,Munshi, S.K.,Sharma, S. Structural basis of human p70 ribosomal S6 kinase-1 regulation by activation loop phosphorylation. J.Biol.Chem., 285:4587-4594, 2010 Cited by PubMed: 19864428 DOI: 10.1074/jbc.M109.040667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation