3WAX

Crystal Structure of Autotaxin in Complex with 3BoA

Summary for 3WAX

Entry DOI	10.2210/pdb3wax/pdb
Related	3WAV 3WAW 3WAY
Descriptor	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, [3-({4-[(5Z)-5-(3,4-dichlorobenzylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperazin-1-yl}methyl)phenyl]boronic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Mus musculus (mouse)
Total number of polymer chains	1
Total formula weight	99721.82
Authors	Nishimasu, H.,Ishitani, R.,Nureki, O. (deposition date: 2013-05-09, release date: 2013-07-31, Last modification date: 2023-11-08)
Primary citation	Kawaguchi, M.,Okabe, T.,Okudaira, S.,Nishimasu, H.,Ishitani, R.,Kojima, H.,Nureki, O.,Aoki, J.,Nagano, T. Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe Acs Chem.Biol., 8:1713-1721, 2013 Cited by PubMed: 23688339 DOI: 10.1021/cb400150c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.899 Å)

Structure validation