311D

THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2

Summary for 311D

• Entry DOI: 10.2210/pdb311d/pdb
• Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), 5-AMIDINO-2-[2-(4-AMIDINOPHENYL)-5-BENZIMIDAZOLYL]BENZIMIDAZOLE (3 entities in total)
• Functional Keywords: b-dna, double helix, complexed with drug, dna
• Total number of polymer chains: 2
• Total formula weight: 7721.22

Authors

Clark, G.R.,Boykin, D.W.,Czarny, A.,Neidle, S. (deposition date: 1997-02-04, release date: 1997-02-11, Last modification date: 2024-02-21)

• Primary citation: Clark, G.R.,Boykin, D.W.,Czarny, A.,Neidle, S.; Structure of a bis-amidinium derivative of hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG)2: the role of hydrogen bonding in minor groove drug-DNA recognition.; Nucleic Acids Res., 25:1510-1515, 1997; PubMed: 9162901; DOI: 10.1093/nar/25.8.1510

Experimental method

X-RAY DIFFRACTION (2.2 Å)