2ZZ0

Crystal structure of human thioredoxin reductase I (SeCys 498 Cys)

Summary for 2ZZ0

Entry DOI	10.2210/pdb2zz0/pdb
Related	2CFY
Descriptor	Thioredoxin reductase 1, cytoplasmic, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... (4 entities in total)
Functional Keywords	rossmann fold, alternative splicing, cytoplasm, electron transport, fad, flavoprotein, nadp, nucleus, oxidoreductase, phosphoprotein, polymorphism, redox-active center, selenium, selenocysteine, transport
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	229487.76
Authors	Lo, Y.C.,Ko, T.P.,Wang, A.H.J. (deposition date: 2009-02-02, release date: 2009-08-18, Last modification date: 2023-11-01)
Primary citation	Lo, Y.C.,Ko, T.P.,Su, W.C.,Su, T.L.,Wang, A.H.J. Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1. J.Inorg.Biochem., 103:1082-1092, 2009 Cited by PubMed: 19525010 DOI: 10.1016/j.jinorgbio.2009.05.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation