2ZYB

Crystal structure of phenylimidazo pyrazin 2 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Summary for 2ZYB

• Entry DOI: 10.2210/pdb2zyb/pdb
• Related: 2ZOB 3LCK
• Descriptor: Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine, ... (4 entities in total)
• Functional Keywords: tyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, alternative splicing, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, kinase, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, cell membrane, polymorphism
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P06239
• Total number of polymer chains: 1
• Total formula weight: 33476.05

Authors

Tsuji, E. (deposition date: 2009-01-19, release date: 2009-02-03, Last modification date: 2023-11-15)

• Primary citation: Ozawa, T.,Tsuji, E.,Ozawa, M.,Handa, C.,Mukaiyama, H.,Nishimura, T.,Kobayashi, S.,Okazaki, K.; The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase; Bioorg.Med.Chem., 16:10311-10318, 2008; PubMed: 18977146; DOI: 10.1016/j.bmc.2008.10.041

Experimental method

X-RAY DIFFRACTION (2.55 Å)