Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2ZPX

TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8

Summary for 2ZPX
Entry DOI10.2210/pdb2zpx/pdb
Related1TNF 1TNR 2EA7 2ZJC
DescriptorTumor necrosis factor (2 entities in total)
Functional Keywordstumor necrosis factor, trimer, antagonistic activity, tnfr1 specific, phage display system, cytokine, cell membrane, lipoprotein, membrane, myristate, phosphoprotein, polymorphism, secreted, signal-anchor, transmembrane
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane; Single-pass type II membrane protein. Tumor necrosis factor, soluble form: Secreted: P01375
Total number of polymer chains3
Total formula weight51850.31
Authors
Mukai, Y.,Nakamura, T.,Yamagata, Y.,Tsutsumi, Y. (deposition date: 2008-07-29, release date: 2009-03-24, Last modification date: 2023-11-01)
Primary citationMukai, Y.,Nakamura, T.,Yoshioka, Y.,Shibata, H.,Abe, Y.,Nomura, T.,Taniai, M.,Ohta, T.,Nakagawa, S.,Tsunoda, S.,Kamada, H.,Yamagata, Y.,Tsutsumi, Y.
Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists
J.Biochem., 146:167-172, 2009
Cited by
PubMed: 19386778
DOI: 10.1093/jb/mvp065
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.83 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon