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2ZO3

Bisphenylic Thrombin Inhibitors

Summary for 2ZO3
Entry DOI10.2210/pdb2zo3/pdb
Related1TA2 2ZC9 2ZDA 2ZNK
Related PRD IDPRD_000601
DescriptorThrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total)
Functional Keywordsblood clotting, hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, gamma-carboxyglutamic acid, glycoprotein, kringle, secreted, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P01050
Total number of polymer chains3
Total formula weight35812.76
Authors
Baum, B.,Heine, A.,Klebe, G. (deposition date: 2008-05-05, release date: 2009-04-14, Last modification date: 2023-11-15)
Primary citationBaum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G.
Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin
J.Mol.Biol., 391:552-564, 2009
Cited by
PubMed: 19520086
DOI: 10.1016/j.jmb.2009.06.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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