2ZO3
Bisphenylic Thrombin Inhibitors
Summary for 2ZO3
Entry DOI | 10.2210/pdb2zo3/pdb |
Related | 1TA2 2ZC9 2ZDA 2ZNK |
Related PRD ID | PRD_000601 |
Descriptor | Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total) |
Functional Keywords | blood clotting, hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, gamma-carboxyglutamic acid, glycoprotein, kringle, secreted, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P01050 |
Total number of polymer chains | 3 |
Total formula weight | 35812.76 |
Authors | |
Primary citation | Baum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin J.Mol.Biol., 391:552-564, 2009 Cited by PubMed: 19520086DOI: 10.1016/j.jmb.2009.06.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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