2ZNP

Human PPAR delta ligand binding domain in complex with a synthetic agonist TIPP204

Summary for 2ZNP

Entry DOI	10.2210/pdb2znp/pdb
Related	2ZNN 2ZNO 2ZNQ
Descriptor	Peroxisome proliferator-activated receptor delta, heptyl beta-D-glucopyranoside, (2S)-2-{4-butoxy-3-[({[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}amino)methyl]benzyl}butanoic acid, ... (4 entities in total)
Functional Keywords	nuclear receptor, protein-ligand complex, ppar, activator, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q03181
Total number of polymer chains	2
Total formula weight	64550.92
Authors	Oyama, T.,Hirakawa, Y.,Nagasawa, N.,Miyachi, H.,Morikawa, K. (deposition date: 2008-04-30, release date: 2009-05-05, Last modification date: 2023-11-01)
Primary citation	Oyama, T.,Toyota, K.,Waku, T.,Hirakawa, Y.,Nagasawa, N.,Kasuga, J.,Hashimoto, Y.,Miyachi, H.,Morikawa, K. Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures Acta Crystallogr.,Sect.D, 65:786-795, 2009 Cited by PubMed: 19622862 DOI: 10.1107/S0907444909015935 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation