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2ZNO

Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703

Summary for 2ZNO
Entry DOI10.2210/pdb2zno/pdb
Related2ZNN 2ZNP 2ZNQ
DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid (3 entities in total)
Functional Keywordsnuclear receptor, protein-ligand complex, ppar, activator, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, receptor, transcription, transcription regulation, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus: P37231
Total number of polymer chains2
Total formula weight66068.65
Authors
Oyama, T.,Waku, T.,Kasuga, J.,Miyachi, H.,Morikawa, K. (deposition date: 2008-04-30, release date: 2009-05-05, Last modification date: 2023-11-01)
Primary citationOyama, T.,Toyota, K.,Waku, T.,Hirakawa, Y.,Nagasawa, N.,Kasuga, J.,Hashimoto, Y.,Miyachi, H.,Morikawa, K.
Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures
Acta Crystallogr.,Sect.D, 65:786-795, 2009
Cited by
PubMed: 19622862
DOI: 10.1107/S0907444909015935
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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