2ZM4

Crystal structure of imidazo quinoxaline 1 bound to the kinase domain of human LCK, activated form (auto-phosphorylated on TYR394)

Summary for 2ZM4

Entry DOI	10.2210/pdb2zm4/pdb
Related	2ZM1 3LCK
Descriptor	Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	tyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, alternative splicing, chromosomal rearrangement, cytoplasm, disease mutation, host-virus interaction, lipoprotein, membrane, myristate, nucleotide-binding, palmitate, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P06239
Total number of polymer chains	1
Total formula weight	33742.77
Authors	Tsuji, E. (deposition date: 2008-04-11, release date: 2008-10-14, Last modification date: 2023-11-15)
Primary citation	Ozawa, T.,Tsuji, E.,Ozawa, M.,Handa, C.,Mukaiyama, H.,Nishimura, T.,Kobayashi, S.,Okazaki, K. The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase Bioorg.Med.Chem., 16:10311-10318, 2008 Cited by PubMed: 18977146 DOI: 10.1016/j.bmc.2008.10.041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation