2ZIZ

Crystal structure of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with NAD and 3-deazaadenosine

Summary for 2ZIZ

Entry DOI	10.2210/pdb2ziz/pdb
Related	1LI4 2ZJ0 2ZJ1 3CE6
Descriptor	Adenosylhomocysteinase, 3-DEAZA-ADENOSINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	protein-substrate complex, dimer of dimers, nad binding domain, 37 amino acid insertional region, hydrolase, one-carbon metabolism
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (By similarity): P60176
Total number of polymer chains	4
Total formula weight	221268.35
Authors	Reddy, M.C.M.,Gokulan, K.,Shetty, N.D.,Owen, J.L.,Ioerger, T.R.,Sacchettini, J.C. (deposition date: 2008-02-29, release date: 2008-09-16, Last modification date: 2023-08-30)
Primary citation	Reddy, M.C.,Kuppan, G.,Shetty, N.D.,Owen, J.L.,Ioerger, T.R.,Sacchettini, J.C. Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Sci., 17:2134-2144, 2008 Cited by PubMed: 18815415 DOI: 10.1110/ps.038125.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation