2ZD8
SHV-1 class A beta-lactamase complexed with meropenem
Summary for 2ZD8
Entry DOI | 10.2210/pdb2zd8/pdb |
Related | 1SHV |
Descriptor | Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | hydrolase, inhibitor, beta-lactam antibiotics, antibiotic resistance |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 30309.70 |
Authors | Nukaga, M.,Knox, J.R.,Hujer, A.,Bonomo, R.A. (deposition date: 2007-11-20, release date: 2008-09-30, Last modification date: 2023-11-01) |
Primary citation | Nukaga, M.,Bethel, C.R.,Thomson, J.M.,Hujer, A.M.,Distler, A.,Anderson, V.E.,Knox, J.R.,Bonomo, R.A. Inhibition of class A beta-lactamases by carbapenems: crystallographic observation of two conformations of meropenem in SHV-1. J.Am.Chem.Soc., 130:12656-12662, 2008 Cited by PubMed: 18761444DOI: 10.1021/ja7111146 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.05 Å) |
Structure validation
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