2ZC3

Penicillin-binding protein 2X (PBP 2X) acyl-enzyme complex (biapenem) from Streptococcus pneumoniae

Summary for 2ZC3

Entry DOI	10.2210/pdb2zc3/pdb
Related	2ZC4 2ZC5 2ZC6
Descriptor	Penicillin-binding protein 2X, (4R,5S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-meth yl-4,5-dihydro-1H-pyrrole-2-carboxylate, SULFATE ION, ... (6 entities in total)
Functional Keywords	peptidoglycan synthesis, cell wall, penicillin-binding, antibiotics, biapenem, antibiotic resistance, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, membrane, secreted, transmembrane, biosynthetic protein
Biological source	Streptococcus pneumoniae More
Cellular location	Cell membrane; Single-pass membrane protein: P59676 P59676 P59676
Total number of polymer chains	6
Total formula weight	149162.95
Authors	Yamada, M.,Watanabe, T.,Takeuchi, Y. (deposition date: 2007-11-02, release date: 2008-04-08, Last modification date: 2023-11-01)
Primary citation	Yamada, M.,Watanabe, T.,Baba, N.,Takeuchi, Y.,Ohsawa, F.,Gomi, S. Crystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniae Antimicrob.Agents Chemother., 52:2053-2060, 2008 Cited by PubMed: 18391040 DOI: 10.1128/AAC.01456-07 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation