2Z7R

Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Staurosporine

Summary for 2Z7R

Entry DOI	10.2210/pdb2z7r/pdb
Related	2Z7Q 2Z7S
Descriptor	Ribosomal protein S6 kinase alpha-1, STAUROSPORINE (3 entities in total)
Functional Keywords	protein kinase, cancer, kinase inhibitor, atp-binding, magnesium, metal-binding, nucleotide-binding, phosphorylation, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37243.92
Authors	Ikuta, M.,Munshi, S.K. (deposition date: 2007-08-28, release date: 2008-05-13, Last modification date: 2023-11-01)
Primary citation	Ikuta, M.,Kornienko, M.,Byrne, N.,Reid, J.C.,Mizuarai, S.,Kotani, H.,Munshi, S.K. Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors. Protein Sci., 16:2626-2635, 2007 Cited by PubMed: 17965187 DOI: 10.1110/ps.073123707 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation