2Z7Q

Crystal structure of the N-terminal kinase domain of human RSK-1 bound to AMP-PCP

Summary for 2Z7Q

• Entry DOI: 10.2210/pdb2z7q/pdb
• Related: 2Z7R 2Z7S
• Descriptor: Ribosomal protein S6 kinase alpha-1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total)
• Functional Keywords: protein kinase; cancer; kinase inhibitor, atp-binding, magnesium, metal-binding, nucleotide-binding, phosphorylation, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q15418
• Total number of polymer chains: 1
• Total formula weight: 37306.90

Authors

Ikuta, M.,Munshi, S.K. (deposition date: 2007-08-28, release date: 2008-05-13, Last modification date: 2023-11-01)

• Primary citation: Ikuta, M.,Kornienko, M.,Byrne, N.,Reid, J.C.,Mizuarai, S.,Kotani, H.,Munshi, S.K.; Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.; Protein Sci., 16:2626-2635, 2007; PubMed: 17965187; DOI: 10.1110/ps.073123707

Experimental method

X-RAY DIFFRACTION (2 Å)