2Z5X

Crystal Structure of Human Monoamine Oxidase A with Harmine

Summary for 2Z5X

Entry DOI	10.2210/pdb2z5x/pdb
Related	2Z5Y
Descriptor	Amine oxidase [flavin-containing] A, FLAVIN-ADENINE DINUCLEOTIDE, 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE, ... (6 entities in total)
Functional Keywords	human monoamine oxidase a, fad, harmine, dimethyldecylphosphine oxide, single helix trans-membrane protein, catecholamine metabolism, flavoprotein, mitochondrion, neurotransmitter degradation, oxidoreductase, transmembrane
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P21397
Total number of polymer chains	1
Total formula weight	59968.56
Authors	Son, S.Y.,Ma, J.,Yoshimura, M.,Tsukihara, T. (deposition date: 2007-07-20, release date: 2008-04-01, Last modification date: 2023-11-01)
Primary citation	Son, S.Y.,Ma, J.,Kondou, Y.,Yoshimura, M.,Yamashita, E.,Tsukihara, T. Structure of human monoamine oxidase A at 2.2-A resolution: The control of opening the entry for substrates/inhibitors Proc.Natl.Acad.Sci.Usa, 105:5739-5744, 2008 Cited by PubMed: 18391214 DOI: 10.1073/pnas.0710626105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation