2Z4B

Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand

Summary for 2Z4B

Entry DOI	10.2210/pdb2z4b/pdb
Related	2I0G 2I0J 2Q70
Descriptor	Estrogen receptor beta, (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (3 entities in total)
Functional Keywords	nuclear receptor ligand binding domain, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q92731
Total number of polymer chains	2
Total formula weight	59093.93
Authors	Wang, Y. (deposition date: 2007-06-14, release date: 2007-08-07, Last modification date: 2024-02-21)
Primary citation	Richardson, T.I.,Dodge, J.A.,Durst, G.L.,Pfeifer, L.A.,Shah, J.,Wang, Y.,Durbin, J.D.,Krishnan, V.,Norman, B.H. Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: Synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification. Bioorg.Med.Chem.Lett., 17:4824-4828, 2007 Cited by PubMed: 17614275 DOI: 10.1016/j.bmcl.2007.06.052 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation