2YCQ

Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115

Summary for 2YCQ

• Entry DOI: 10.2210/pdb2ycq/pdb
• Related: 1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XM8 2XM9 2YCF 2YCR 2YCS
• Descriptor: SERINE/THREONINE-PROTEIN KINASE CHK2, N-{4-[(1E)-N-1H-IMIDAZOL-2-YLETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, ... (4 entities in total)
• Functional Keywords: transferase, anticancer drug design
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
• Total number of polymer chains: 1
• Total formula weight: 37027.64

Authors

Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Pommier, Y.,Shoemaker, R.H.,Zhang, G.,Waugh, D.S. (deposition date: 2011-03-16, release date: 2011-11-16, Last modification date: 2023-12-20)

• Primary citation: Lountos, G.T.,Jobson, A.G.,Tropea, J.E.,Self, C.R.,Zhang, G.,Pommier, Y.,Shoemaker, R.H.,Waugh, D.S.; Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.; J.Struct.Biol., 176:292-, 2011; PubMed: 21963792; DOI: 10.1016/J.JSB.2011.09.008

Experimental method

X-RAY DIFFRACTION (2.05 Å)