2YBP

JMJD2A COMPLEXED WITH R-2-HYDROXYGLUTARATE AND HISTONE H3K36me3 PEPTIDE (30-41)

Summary for 2YBP

• Entry DOI: 10.2210/pdb2ybp/pdb
• Related: 2GF7 2GFA 2GP3 2GP5 2V1D 2VD7 2WWJ 2YBK 2YBS
• Descriptor: LYSINE-SPECIFIC DEMETHYLASE 4A, HISTONE H3.1T, NICKEL (II) ION, ... (7 entities in total)
• Functional Keywords: oxidoreductase-peptide complex, non-heme iron, dioxygenase, double-stranded beta helix, dsbh, facial triad, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation, oxidoreductase/peptide
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 4
• Total formula weight: 92002.30

Authors

Chowdhury, R.,McDonough, M.A.,Schofield, C.J. (deposition date: 2011-03-09, release date: 2011-03-30, Last modification date: 2023-12-20)

• Primary citation: Chowdhury, R.,Yeoh, K.K.,Tian, Y.M.,Hillringhaus, L.,Bagg, E.A.,Rose, N.R.,Leung, I.K.,Li, X.S.,Woon, E.C.,Yang, M.,McDonough, M.A.,King, O.N.,Clifton, I.J.,Klose, R.J.,Claridge, T.D.,Ratcliffe, P.J.,Schofield, C.J.,Kawamura, A.; The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.; EMBO Rep., 12:463-469, 2011; PubMed: 21460794; DOI: 10.1038/embor.2011.43

Experimental method

X-RAY DIFFRACTION (2.02 Å)