2YA8
Crystal structure of Streptococcus pneumoniae NanA (TIGR4) in complex with Oseltamivir carboxylate
Summary for 2YA8
| Entry DOI | 10.2210/pdb2ya8/pdb |
| Descriptor | NEURAMINIDASE A, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CHLORIDE ION, ... (6 entities in total) |
| Functional Keywords | hydrolase, sialidase |
| Biological source | STREPTOCOCCUS PNEUMONIAE |
| Total number of polymer chains | 2 |
| Total formula weight | 111703.28 |
| Authors | Gut, H.,Xu, G.,Taylor, G.L.,Walsh, M.A. (deposition date: 2011-02-18, release date: 2011-04-27, Last modification date: 2020-09-02) |
| Primary citation | Gut, H.,Xu, G.,Taylor, G.L.,Walsh, M.A. Structural Basis for Streptococcus Pneumoniae Nana Inhibition by Influenza Antivirals Zanamivir and Oseltamivir Carboxylate. J.Mol.Biol., 409:496-, 2011 Cited by PubMed: 21514303DOI: 10.1016/J.JMB.2011.04.016 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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