2Y5K
Orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase
Summary for 2Y5K
Entry DOI | 10.2210/pdb2y5k/pdb |
Related | 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5L |
Descriptor | FRUCTOSE-1,6-BISPHOSPHATASE 1, 1-[5-(2-METHOXYETHYL)-4-METHYL-THIOPHEN-2-YL]SULFONYL-3-[4-METHOXY-6-(METHYLCARBAMOYLAMINO)PYRIDIN-2-YL]UREA (3 entities in total) |
Functional Keywords | hydrolase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 4 |
Total formula weight | 149267.77 |
Authors | Ruf, A.,Hebeisen, P.,Haap, W.,Kuhn, B.,Mohr, P.,Wessel, H.P.,Zutter, U.,Kirchner, S.,Benz, J.,Joseph, C.,Alvarez-Sanchez, R.,Gubler, M.,Schott, B.,Benardeau, A.,Tozzo, E.,Kitas, E. (deposition date: 2011-01-14, release date: 2011-05-18, Last modification date: 2023-12-20) |
Primary citation | Hebeisen, P.,Haap, W.,Kuhn, B.,Mohr, P.,Wessel, H.P.,Zutter, U.,Kirchner, S.,Ruf, A.,Benz, J.,Joseph, C.,Alvarez-Sanchez, R.,Gubler, M.,Schott, B.,Benardeau, A.,Tozzo, E.,Kitas, E. Orally Active Aminopyridines as Inhibitors of Tetrameric Fructose-1,6-Bisphosphatase. Bioorg.Med.Chem.Lett., 21:3237-, 2011 Cited by PubMed: 21550236DOI: 10.1016/J.BMCL.2011.04.044 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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