2XWR

Crystal structure of the DNA-binding domain of human p53 with extended N terminus

Summary for 2XWR

• Entry DOI: 10.2210/pdb2xwr/pdb
• Related: 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAH 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2FEJ 2FOJ 2FOO 2GS0 2H1L 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2VUK 2WGX 2X0U 2X0V 2X0W 2YBG 3SAK
• Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total)
• Functional Keywords: cell cycle, cancer, transcription factor, apoptosis
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 46303.34

Authors

Joerger, A.C.,Natan, E.,Fersht, A.R. (deposition date: 2010-11-04, release date: 2011-03-30, Last modification date: 2019-05-08)

• Primary citation: Natan, E.,Baloglu, C.,Pagel, K.,Freund, S.M.,Morgner, N.,Robinson, C.V.,Fersht, A.R.,Joerger, A.C.; Interaction of the P53 DNA-Binding Domain with its N-Terminal Extension Modulates the Stability of the P53 Tetramer.; J.Mol.Biol., 409:358-, 2011; PubMed: 21457718; DOI: 10.1016/J.JMB.2011.03.047

Experimental method

X-RAY DIFFRACTION (1.68 Å)