2XJ2
Protein kinase Pim-1 in complex with small molecule inhibitor
Summary for 2XJ2
Entry DOI | 10.2210/pdb2xj2/pdb |
Related | 1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIX 2XIY 2XIZ 2XJ0 2XJ1 |
Descriptor | PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid (3 entities in total) |
Functional Keywords | transferase, phosphorylation, protein kinase fold |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 34727.34 |
Authors | Schulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C. (deposition date: 2010-07-01, release date: 2011-02-23, Last modification date: 2011-07-13) |
Primary citation | Schulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C. Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors Acta Crystallogr.,Sect.D, 67:156-, 2011 Cited by PubMed: 21358046DOI: 10.1107/S0907444910054144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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