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2XIX

Protein kinase Pim-1 in complex with fragment-1 from crystallographic fragment screen

Summary for 2XIX
Entry DOI10.2210/pdb2xix/pdb
Related1XQZ 1XR1 1XWS 1YHS 1YI3 1YI4 1YWV 1YXS 1YXT 1YXU 1YXV 1YXX 2BIK 2BIL 2BZH 2BZI 2BZJ 2BZK 2C3I 2J2I 2XIY 2XIZ 2XJ0 2XJ1 2XJ2
DescriptorPROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3,5-DIAMINO-1H-[1,2,4]TRIAZOLE (3 entities in total)
Functional Keywordsatp-binding, phosphorylation, transferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains1
Total formula weight34568.01
Authors
Schulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C. (deposition date: 2010-07-01, release date: 2011-02-23, Last modification date: 2011-07-13)
Primary citationSchulz, M.N.,Fanghanel, J.,Schafer, M.,Badock, V.,Briem, H.,Boemer, U.,Nguyen, D.,Husemann, M.,Hillig, R.C.
Crystallographic Fragment Screen Identifies Cinnamic Acid Derivatives as Starting Points for Potent Pim-1 Inhibitors
Acta Crystallogr.,Sect.D, 67:156-, 2011
Cited by
PubMed: 21358046
DOI: 10.1107/S0907444910054144
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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