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2XHX

Structure of HSP90 with small molecule inhibitor bound

Summary for 2XHX
Entry DOI10.2210/pdb2xhx/pdb
Related1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2CDD 2FWY 2FWZ 2JJC 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT
DescriptorHEAT SHOCK PROTEIN HSP 90-ALPHA, 2-TERT-BUTYL-4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)PHENOL (3 entities in total)
Functional Keywordshsp90, chaperone, atp binding domain, n-terminal domain, stress response
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm: P07900
Total number of polymer chains1
Total formula weight28268.74
Authors
Primary citationMurray, C.W.,Carr, M.G.,Callaghan, O.,Chessari, G.,Congreve, M.,Cowan, S.,Coyle, J.E.,Downham, R.,Figueroa, E.,Frederickson, M.,Graham, B.,Mcmenamin, R.,O'Brien, M.A.,Patel, S.,Phillips, T.R.,Williams, G.,Woodhead, A.J.,Woolford, A.J.A.
Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency.
J.Med.Chem., 53:5942-, 2010
Cited by
PubMed: 20718493
DOI: 10.1021/JM100059D
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.801 Å)
Structure validation

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