2XA4

Inhibitors of Jak2 Kinase domain

Summary for 2XA4

Entry DOI	10.2210/pdb2xa4/pdb
Related	2B7A 2W1I
Descriptor	TYROSINE-PROTEIN KINASE JAK2, 5-CHLORO-N2-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHYL]-N4-(5-METHYL-1H-PYRAZOL-3-YL)PYRIMIDINE-2,4-DIAMINE (3 entities in total)
Functional Keywords	kinase, membrane, transferase, atp-binding, proto-oncogene, phosphoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	70861.11
Authors	Read, J.,Green, I.,Pollard, H.,Howard, T.,Mott, R. (deposition date: 2010-03-26, release date: 2010-12-15, Last modification date: 2019-05-08)
Primary citation	Ioannidis, S.,Lamb, M.L.,Wang, T.,Almeida, L.,Block, M.H.,Davies, A.M.,Peng, B.,Su, M.,Zhang, H.,Hoffmann, E.,Rivard, C.,Green, I.,Howard, T.,Pollard, H.,Read, J.,Alimzhanov, M.,Bebernitz, G.,Bell, K.,Ye, M.,Huszar, D.,Zinda, M. Discovery of 5-Chloro-N2-[(1S)-1-(5-Fluoropyrimidin-2-Yl) Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine (Azd1480) as a Novel Inhibitor of the Jak/Stat Pathway J.Med.Chem., 54:262-, 2011 Cited by PubMed: 21138246 DOI: 10.1021/JM1011319 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation