2XA0

Crystal structure of BCL-2 in complex with a BAX BH3 peptide

Summary for 2XA0

• Entry DOI: 10.2210/pdb2xa0/pdb
• Related: 1G5M 1GJH 1YSW 2W3L
• Descriptor: APOPTOSIS REGULATOR BCL-2, APOPTOSIS REGULATOR BAX (3 entities in total)
• Functional Keywords: apoptosis, cell death
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Mitochondrion outer membrane; Single-pass membrane protein: P10415; Isoform Alpha: Mitochondrion outer membrane; Single-pass membrane protein (By similarity). Isoform Beta: Cytoplasm (By similarity). Isoform Gamma: Cytoplasm (By similarity): Q07813
• Total number of polymer chains: 4
• Total formula weight: 52867.50

Authors

Ku, B.,Oh, B.H. (deposition date: 2010-03-25, release date: 2010-11-24, Last modification date: 2023-12-20)

• Primary citation: Ku, B.,Liang, C.,Jung, J.U.,Oh, B.H.; Evidence that Inhibition of Bax Activation by Bcl- 2 Involves its Tight and Preferential Interaction with the Bh3 Domain of Bax.; Cell Res., 21:627-, 2011; PubMed: 21060336; DOI: 10.1038/CR.2010.149

Experimental method

X-RAY DIFFRACTION (2.7 Å)