2X7O

Crystal structure of TGFbRI complexed with an indolinone inhibitor

Summary for 2X7O

Entry DOI	10.2210/pdb2x7o/pdb
Related	1B6C 1IAS 1PY5 1RW8 1VJY 2WOT 2WOU
Descriptor	TGF-BETA RECEPTOR TYPE I, (3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE (2 entities in total)
Functional Keywords	kinase, transferase, glycoprotein
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	5
Total formula weight	197076.34
Authors	Roth, G.J.,Heckel, A.,Brandl, T.,Grauert, M.,Hoerer, S.,Kley, J.T.,Schnapp, G.,Baum, P.,Mennerich, D.,Schnapp, A.,Park, J.E. (deposition date: 2010-03-03, release date: 2010-10-20, Last modification date: 2023-12-20)
Primary citation	Roth, G.J.,Heckel, A.,Brandl, T.,Grauert, M.,Hoerer, S.,Kley, J.T.,Schnapp, G.,Baum, P.,Mennerich, D.,Schnapp, A.,Park, J.E. Design, Synthesis and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor Beta Receptor I (Tgfbri) J.Med.Chem., 53:7287-, 2010 Cited by PubMed: 20919678 DOI: 10.1021/JM100812A PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation