2X6U

Crystal structure of human TBX5 in the DNA-free form

Summary for 2X6U

• Entry DOI: 10.2210/pdb2x6u/pdb
• Related: 2X6V
• Descriptor: T-BOX TRANSCRIPTION FACTOR TBX5, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: developmental protein, dna-binding, holt-oram-syndrome, ig-fold, nuclear protein, repressor, tbx3, transcription, transcription regulation
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus (Potential): Q99593
• Total number of polymer chains: 1
• Total formula weight: 23857.75

Authors

Stirnimann, C.U.,Mueller, C.W. (deposition date: 2010-02-22, release date: 2010-04-28, Last modification date: 2011-07-13)

• Primary citation: Stirnimann, C.U.,Ptchelkine, D.,Grimm, C.,Muller, C.W.; Structural Basis of Tbx5-DNA Recognition: The T-Box Domain in its DNA-Bound and -Unbound Form.; J.Mol.Biol., 400:71-, 2010; PubMed: 20450920; DOI: 10.1016/J.JMB.2010.04.052

Experimental method

X-RAY DIFFRACTION (1.9 Å)