2X6M

Structure of a single domain camelid antibody fragment in complex with a C-terminal peptide of alpha-synuclein

Summary for 2X6M

• Entry DOI: 10.2210/pdb2x6m/pdb
• Related: 1XQ8
• Descriptor: HEAVY CHAIN VARIABLE DOMAIN FROM DROMEDARY, ALPHA-SYNUCLEIN PEPTIDE (3 entities in total)
• Functional Keywords: immune system, parkinson's disease, alzheimer disease amyloid, nanobody, affinity tag
• Biological source: CAMELUS DROMEDARIUS (DROMEDARY); More
• Total number of polymer chains: 2
• Total formula weight: 14508.87

Authors

DeGenst, E.,Guilliams, T.,Wellens, J.,O'Day, E.M.,Waudby, C.A.,Meehan, S.,Dumoulin, M.,Hsu, S.-T.D.,Cremades, N.,Verschueren, K.H.G.,Pardon, E.,Wyns, L.,Steyaert, J.,Christodoulou, J.,Dobson, C.M. (deposition date: 2010-02-18, release date: 2010-06-23, Last modification date: 2023-12-20)

• Primary citation: De Genst, E.J.,Guilliams, T.,Wellens, J.,O'Day, E.M.,Waudby, C.A.,Meehan, S.,Dumoulin, M.,Hsu, S.-T.D.,Cremades, N.,Verschueren, K.H.G.,Pardon, E.,Wyns, L.,Steyaert, J.,Christodoulou, J.,Dobson, C.M.; Structure and Properties of a Complex of Alpha-Synuclein and a Single-Domain Camelid Antibody.; J.Mol.Biol., 402:326-, 2010; PubMed: 20620148; DOI: 10.1016/J.JMB.2010.07.001

Experimental method

X-RAY DIFFRACTION (1.62 Å)