2X2L

Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor

Summary for 2X2L

Entry DOI	10.2210/pdb2x2l/pdb
Related	2IVS 2IVT 2IVU 2IVV 2X2K 2X2M
Descriptor	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET, FORMIC ACID, (3Z)-5-AMINO-3-[(4-METHOXYPHENYL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE, ... (4 entities in total)
Functional Keywords	hirschsprung disease, gdnf receptor, transmembrane, proto-oncogene, phosphoprotein, disease mutation, phosphotransferase, ret, kinase, membrane, transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	36238.61
Authors	Knowles, P.P.,Murray-Rust, J.,Kjaer, S.,McDonald, N.Q. (deposition date: 2010-01-13, release date: 2010-02-09, Last modification date: 2023-12-20)
Primary citation	Mologni, L.,Rostagno, R.,Brussolo, S.,Knowles, P.P.,Kjaer, S.,Murray-Rust, J.,Rosso, E.,Zambon, A.,Scapozza, L.,McDonald, N.Q.,Lucchini, V.,Gambacorti-Passerini, C. Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors. Bioorg. Med. Chem., 18:1482-1496, 2010 Cited by PubMed: 20117004 DOI: 10.1016/j.bmc.2010.01.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation