2X04

Crystal structure of the PABC-TNRC6C complex

Summary for 2X04

Entry DOI	10.2210/pdb2x04/pdb
Related	1CVJ 1G9L 1JGN 1JH4 2DKL
Descriptor	POLYADENYLATE-BINDING PROTEIN 1, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN, SULFATE ION, ... (4 entities in total)
Functional Keywords	peptide-rna binding protein complex, rna-mediated gene silencing, nucleus, methylation, spliceosome, translation regulation, protein-protein complex, coiled coil, deadenylation, mrna splicing, phosphoprotein, mrna processing, microrna silencing, peptide/rna binding protein
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Cytoplasm: P11940
Total number of polymer chains	4
Total formula weight	21566.78
Authors	Jinek, M.,Fabian, M.R.,Coyle, S.M.,Sonenberg, N.,Doudna, J.A. (deposition date: 2009-12-04, release date: 2010-01-19, Last modification date: 2011-07-13)
Primary citation	Jinek, M.,Fabian, M.R.,Coyle, S.M.,Sonenberg, N.,Doudna, J.A. Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation Nat.Struct.Mol.Biol., 17:238-, 2010 Cited by PubMed: 20098421 DOI: 10.1038/NSMB.1768 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49 Å)

Structure validation