2WVJ

Mutation of Thr163 to Ser in Human Thymidine Kinase Shifts the Specificity from Thymidine towards the Nucleoside Analogue Azidothymidine

Summary for 2WVJ

Entry DOI	10.2210/pdb2wvj/pdb
Related	1W4R 1XBT 2WVL
Descriptor	THYMIDINE KINASE, CYTOSOLIC, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION, ... (5 entities in total)
Functional Keywords	zinc-binding domain, deoxyribonucleoside kinase, feedback inhibitor, nucleotide-binding, kinase, cytoplasm, transferase, atp-binding, dna synthesis, phosphoprotein, phosphorylation
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	8
Total formula weight	174957.33
Authors	Skovgaard, T.,Uhlin, U.,Munch-Petersen, B. (deposition date: 2009-10-17, release date: 2009-10-27, Last modification date: 2023-12-20)
Primary citation	Skovgaard, T.,Uhlin, U.,Munch-Petersen, B. Comparative Active-Site Mutation Study of Human and Caenorhabditis Elegans Thymidine Kinase 1. FEBS J., 279:1777-, 2012 Cited by PubMed: 22385435 DOI: 10.1111/J.1742-4658.2012.08554.X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation